FAQ

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

Known as: 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity, hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity, AMPK 
Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1969-2017
05101519692017

Related topics

Related topics

3 relations
AMP-Activated Protein KinasesPRKAA2 wt AllelecAMP-dependent protein kinase activity

Related mentions per year

Related mentions per year

1958-2018
1960198020002020
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
AMP-Activated Protein Kinases
PRKAA2 wt Allele
cAMP-dependent protein kinase activity

Papers overview

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Highly Cited
2004
Highly Cited
2004
Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure.
OBJECTIVES This study aimed to investigate the impact of hydroxymethylglutaryl coenzyme A reductase inhibitor (statin) therapy in… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development.
Several prospective clinical studies have indicated that hydroxymethylglutaryl-coenzyme A reductase inhibitors, statins, prevent… (More)
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Highly Cited
2003
Highly Cited
2003
Statin effects on cholesterol micro-domains in brain plasma membranes.
Recent epidemiological studies revealed inhibitors of the hydroxymethylglutaryl-coenzyme A reductase, so-called statins, to be… (More)
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Highly Cited
2002
Highly Cited
2002
Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction.
BACKGROUND The early response of C-reactive protein to initiation of a hydroxymethylglutaryl coenzyme A reductase inhibitor… (More)
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Highly Cited
2001
Highly Cited
2001
Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia.
BACKGROUND Long-term therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) has been shown to reduce levels… (More)
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Highly Cited
2001
Highly Cited
2001
Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction.
BACKGROUND Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) attenuate angiotensin II-induced cellular signaling… (More)
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Highly Cited
2001
Highly Cited
2001
Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.
BACKGROUND The short-term effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) on endothelial function at… (More)
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Highly Cited
2001
Highly Cited
2001
Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy.
BACKGROUND Elevated oxidative stress and superoxide anion formation in vascular cells could promote conversion of LDL to… (More)
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Highly Cited
2000
Highly Cited
2000
Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae.
BACKGROUND In patients with atherosclerosis, hepatic hydroxymethylglutaryl coenzyme A reductase (CSE) inhibitors may reduce the… (More)
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Highly Cited
1984
Highly Cited
1984
Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.
Support for the role of a cytosolic oxysterol-binding protein in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA… (More)
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