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(11C)N-desmethyl-loperamide

Known as: (11C)dLop, Carbon C 11 N-desmethyl-Loperamide 
A radiopharmaceutical containing N-desmethyl loperamide (dLop) labeled with carbon 11 (11C), used to measure the activity of efflux transporter P… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
INTRODUCTION We investigated placental transfer and neurobehavioural effects in neonates exposed to citalopram, escitalopram… Expand
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Highly Cited
2009
Highly Cited
2009
Tamoxifen has been the most important therapeutic agent for the treatment of estrogen receptor (ER)-positive breast cancer for… Expand
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Highly Cited
2008
Highly Cited
2008
We sought to develop (11)C-labeled ligands for sensitive imaging of brain peripheral benzodiazepine receptors (PBR) in vivo. Two… Expand
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Highly Cited
2004
Highly Cited
2004
The antiestrogen tamoxifen is extensively metabolized in patients to form a series of compounds with altered affinity for… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active… Expand
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Highly Cited
2003
Highly Cited
2003
Despite the remarkable clinical response rates to imatinib in the treatment of bcr-abl leukemic patients, pharmacokinetic data on… Expand
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Highly Cited
2000
Highly Cited
2000
The soy isoflavones, daidzein and genistein, and the lignans, matairesinol and secoisolariciresinol, are phytoestrogens… Expand
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Highly Cited
2000
Highly Cited
2000
An in vitro model is proposed to account for the clinically observed inhibition of cytochrome P450 (CYP) 3A that results from… Expand
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Highly Cited
2000
Highly Cited
2000
Two novel tocotrienols were isolated from stabilized and heated rice bran, apart from the known alpha-, beta-, gamma-, and delta… Expand
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Highly Cited
1997
Highly Cited
1997
Both the R(+) and the S(-) enantiomers of carvedilol were metabolized in human liver microsomes primarily to 4'- (4OHC) and 5… Expand
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