zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline.

@article{Pane2007zucchiniAS,
  title={zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline.},
  author={Attilio Pane and Kristina Wehr and Trudi Sch{\"u}pbach},
  journal={Developmental cell},
  year={2007},
  volume={12 6},
  pages={851-62}
}
RNAi is a widespread mechanism by which organisms regulate gene expression and defend their genomes against viruses and transposable elements. Here we report the identification of Drosophila zucchini (zuc) and squash (squ), which function in germline RNAi processes. Zuc and Squ contain domains with homologies to nucleases. Mutant females are sterile and show dorsoventral patterning defects during oogenesis. In addition, Oskar protein is ectopically expressed in early oocytes, where it is… CONTINUE READING
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