xol-1: a gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans.

@article{Miller1988xol1AG,
  title={xol-1: a gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans.},
  author={Leilani M Miller and John D. Plenefisch and L P Casson and Barbara J Meyer},
  journal={Cell},
  year={1988},
  volume={55 1},
  pages={167-83}
}
Loss-of-function mutations in the X-linked gene xol-1 cause the feminization and death of XO animals (normally males) by shifting the sex determination and dosage compensation pathways toward their hermaphrodite modes. XO-specific lethality most likely results from the reduction in X chromosome expression caused by xol-1 mutations. Mutations in genes required for the hermaphrodite mode of dosage compensation suppress lethality but not feminization, and restore X chromosome expression to nearly… CONTINUE READING

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