xo1-1 acts as an early switch in the C. elegans male/hermaphrodite decision

@article{Rhind1995xo11AA,
  title={xo1-1 acts as an early switch in the C. elegans male/hermaphrodite decision},
  author={Nicholas Rhind and Leilani M Miller and Jennifer B. Kopczynski and Barbara J Meyer},
  journal={Cell},
  year={1995},
  volume={80},
  pages={71-82}
}
xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male development, whereas low expression at that time permits hermaphrodite development. Inappropriately high xol-1 expression causes hermaphrodites to activate the male program of… CONTINUE READING