wnt3a but not wnt11 supports self-renewal of embryonic stem cells.

  title={wnt3a but not wnt11 supports self-renewal of embryonic stem cells.},
  author={Dinender K Singla and David J. Schneider and Martin Lewinter and B. E. Sobel},
  journal={Biochemical and biophysical research communications},
  volume={345 2},
wnt proteins (wnts) promote both differentiation of midbrain dopaminergic cells and self-renewal of haematopoietic stem cells. Mouse embryonic stem (ES) cells can be maintained and self-renew on mouse feeder cell layers or in media containing leukemia inhibitory factor (LIF). However, the effects of wnts on ES cells self-renewal and differentiation are not clearly understood. In the present study, we found that conditioned medium prepared from L cells expressing wnt3a can replace feeder cell… CONTINUE READING
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