wishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila

@article{Aberle2002wishfulTE,
  title={wishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila},
  author={Hermann Aberle and Asghar Haghighi and Richard D Fetter and Brian D McCabe and Tiago R. Magalh{\~a}es and Corey S. Goodman},
  journal={Neuron},
  year={2002},
  volume={33},
  pages={545-558}
}
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evoked excitatory junctional potentials, decreased levels of the synaptic cell adhesion molecule Fasciclin… CONTINUE READING
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