• Published 2007

which It Specifically Inhibits Tumorigenesis Cyclooxygenase-2 and Osteopontin under Conditions in Dominant-Negative Activator Protein 1 ( TAM 67 ) Targets

@inproceedings{Matthews2007whichIS,
  title={which It Specifically Inhibits Tumorigenesis Cyclooxygenase-2 and Osteopontin under Conditions in Dominant-Negative Activator Protein 1 ( TAM 67 ) Targets},
  author={Phillip M. Matthews and Alysia M. Birkholz and Alyson R. Baker and Christine M. Perella and George R. Beck and M Rita I Young and Nancy Hall Colburn},
  year={2007}
}
Activation of activator protein 1 (AP-1) and nuclear factor KB (NFKB)–dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFKB activation by interacting with NFKB p65. Two-stage [7,12dimethylbenz(a)anthracene (DMBA)/12-O -tetradecanoylphorbol-13-acetate (TPA)] skin carcinogenesis experiments in a model relevant to human cancer risk… CONTINUE READING

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