walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.

@article{Shoji2011walKAC,
  title={walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.},
  author={Mitsutaka Shoji and Longzhu Cui and Risa Iizuka and Akira Komoto and Hui-min Neoh and Yukiko Watanabe and Tomomi Hishinuma and Keiichi Hiramatsu},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 8},
  pages={3870-81}
}
Vancomycin-intermediate Staphylococcus aureus (VISA) is generated from vancomycin-susceptible Staphylococcus aureus by multiple spontaneous mutations. We previously reported that sequential acquisition of mutations in the two-component regulatory systems vraSR and graRS was responsible for the VISA phenotype of strain Mu50. Here we report on the identification of a novel set of regulator mutations, a deletion mutation in two-component regulatory system walRK (synonyms, vicRK and yycFG), and a… CONTINUE READING