von Willebrand factor propeptide: biology and clinical utility.

  title={von Willebrand factor propeptide: biology and clinical utility.},
  author={Sandra L. Haberichter},
  volume={126 15},
von Willebrand factor (VWF) is a large multimeric glycoprotein that mediates the attachment of platelets to damaged endothelium and also serves as the carrier protein for coagulation factor VIII (FVIII), protecting it from proteolytic degradation. Quantitative or qualitative defects in VWF result in von Willebrand disease (VWD), a common inherited bleeding disorder. VWF is synthesized with a very large propeptide (VWFpp) that is critical for intracellular processing of VWF. VWFpp actively… CONTINUE READING
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