von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.

Abstract

Deep vein thrombosis (DVT) and its complication, pulmonary embolism, are frequent causes of disability and mortality. Although blood flow disturbance is considered an important triggering factor, the mechanism of DVT initiation remains elusive. Here we show that 48-hour flow restriction in the inferior vena cava (IVC) results in the development of thrombi… (More)
DOI: 10.1182/blood-2010-05-287623

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@article{Brill2011vonWF, title={von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.}, author={Alexander Brill and Tobias A. Fuchs and Anil K Chauhan and Janie J. Yang and Simon F De Meyer and Maria Koellnberger and Thomas W. Wakefield and Bernhard L{\"a}mmle and Steffen Massberg and Denisa D Wagner}, journal={Blood}, year={2011}, volume={117 4}, pages={1400-7} }