von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis.

@article{Noubade2008vonWillebrandFI,
  title={von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis.},
  author={Rajkumar Noubade and Roxana del Rio and Benjamin D McElvany and James F. Zachary and Jason Michael Millward and Denisa D Wagner and Halina Offner and Elizabeth P. Blankenhorn and Cory Teuscher},
  journal={The American journal of pathology},
  year={2008},
  volume={173 3},
  pages={
          892-900
        }
}
Weibel-Palade bodies within endothelial cells are secretory granules known to release von Willebrand Factor (VWF), P-selectin, chemokines, and other stored molecules following histamine exposure. Mice with a disrupted VWF gene (VWFKO) have endothelial cells that are deficient in Weibel-Palade bodies. These mice were used to evaluate the role of VWF and/or Weibel-Palade bodies in Bordetella pertussis toxin-induced hypersensitivity to histamine, a subphenotype of experimental allergic… CONTINUE READING
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