von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.

@article{Remuzzi2002vonWF,
  title={von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.},
  author={Giuseppe Remuzzi and Miriam Galbusera and Marina Noris and Maria Teresa Canciani and Erica Daina and Elena Bresin and Silvia Contaretti and Jessica Caprioli and Sara Gamba and Piero Ruggenenti and Norberto Perico and Pier Mannuccio Mannucci},
  journal={Blood},
  year={2002},
  volume={100 3},
  pages={778-85}
}
Whether measurement of ADAMTS13 activity may enable physicians to distinguish thrombotic thrombocytopenic purpura (TTP) from hemolytic uremic syndrome (HUS) is still a controversial issue. Our aim was to clarify whether patients with normal or deficient ADAMTS13 activity could be distinguished in terms of disease manifestations and multimeric patterns of plasma von Willebrand factor (VWF). ADAMTS13 activity, VWF antigen, and multimeric pattern were evaluated in patients with recurrent and… CONTINUE READING

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