von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends.

  title={von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends.},
  author={Peter J. Lenting and Olivier D. Christophe and C{\'e}cile V. Denis},
  volume={125 13},
To understand the placement of a certain protein in a physiological system and the pathogenesis of related disorders, it is not only of interest to determine its function but also important to describe the sequential steps in its life cycle, from synthesis to secretion and ultimately its clearance. von Willebrand factor (VWF) is a particularly intriguing case in this regard because of its important auxiliary roles (both intra- and extracellular) that implicate a wide range of other proteins… 

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  • J. Sadler
  • Biology, Medicine
    Annual review of biochemistry
  • 1998
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