von Willebrand factor and development of diabetic nephropathy in IDDM.

@article{Stehouwer1991vonWF,
  title={von Willebrand factor and development of diabetic nephropathy in IDDM.},
  author={Coen D A Stehouwer and Erik S. G. Stroes and W. H. L. Hackeng and Paul G. H. Mulder and G. J. den Ottolander},
  journal={Diabetes},
  year={1991},
  volume={40 8},
  pages={971-6}
}
We tested the hypothesis that dysfunction of vascular endothelium, indicated by an increase in plasma level of von Willebrand factor (vWF), is present in patients with insulin-dependent diabetes mellitus (IDDM) who develop diabetic nephropathy (DN). DN was classified as absent (urinary albumin excretion [UAE] rate less than 15 microgram/min), incipient (UAE rate 15-200 micrograms/min), or clinical (UAE rate greater than 200 micrograms/min). We followed a cohort of 59 patients for a median of 3… CONTINUE READING