von Hippel-Lindau tumor suppressor: not only HIF's executioner.

  title={von Hippel-Lindau tumor suppressor: not only HIF's executioner.},
  author={Maria F. Czyzyk-Krzeska and Jaroslaw Meller},
  journal={Trends in molecular medicine},
  volume={10 4},
Loss of von Hippel-Lindau (VHL) protein function results in an autosomal-dominant cancer syndrome known as VHL disease, which manifests as angiomas of the retina, hemangioblastomas of the central nervous system, renal clear-cell carcinomas and pheochromocytomas. VHL tumor suppressor is a specific substrate-recognition component of the E3 ubiquitin complex, which regulates proteasomal degradation of the subunit of the hypoxia inducible transcription factor (HIF). Impaired VHL complex function… CONTINUE READING