Corpus ID: 38659259

von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.

@article{LieubeauTeillet1998vonHG,
  title={von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.},
  author={B. Lieubeau-Teillet and J. Rak and S. Jothy and O. Iliopoulos and W. Kälin and R. Kerbel},
  journal={Cancer research},
  year={1998},
  volume={58 21},
  pages={
          4957-62
        }
}
  • B. Lieubeau-Teillet, J. Rak, +3 authors R. Kerbel
  • Published 1998
  • Biology, Medicine
  • Cancer research
  • Previous results using gene transfection methods have shown that the wild-type (WT) von Hippel-Lindau (VHL) gene can function as a potent tumor suppressor gene in vivo for renal cell carcinoma (RCC) cells in the absence of any suppressive effect on cell growth in monolayer cell culture under serum-rich conditions. Because we had previously found that the function of some oncogenes, such as mutant ras, can be influenced by three-dimensional growth as multicellular spheroids (J. Rak et aL, J… CONTINUE READING
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