vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.

Abstract

A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.

DOI: 10.1128/JB.01771-08

Cite this paper

@article{Ma2009vfrAN, title={vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.}, author={Yongsheng Ma and Amy E Bryant and Dan B Salmi and Eric R. McIndoo and Dennis Leroy Stevens}, journal={Journal of bacteriology}, year={2009}, volume={191 9}, pages={3189-94} }