v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.

@article{Leder1990vHarasTA,
  title={v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.},
  author={Aya Leder and Ann Kuo and Robert Cardiff and Eric Sinn and Philip Leder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 23},
  pages={9178-82}
}
Experimental carcinogenesis has led to a concept that defines two discrete stages in the development of skin tumors: (i) initiation, which is accomplished by using a mutagen that presumably activates a protooncogene, and (ii) promotion, which is a reversible process brought about most commonly by repeated application of phorbol esters. We have created a transgenic mouse strain that carries the activated v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like, zeta-globin gene… CONTINUE READING

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