ubtle changes in TCR CDR 1 profoundly increase the sensitivity of CD 4 T cells

@inproceedings{Lyncha2012ubtleCI,
  title={ubtle changes in TCR CDR 1 profoundly increase the sensitivity of CD 4 T cells},
  author={ennifer N. Lyncha and David L. Donermeyera and K. Scott Webera and David M. Kranzb and Paul M. Allena},
  year={2012}
}
  • ennifer N. Lyncha, David L. Donermeyera, +2 authors Paul M. Allena
  • Published 2012
Changes in the peptide and MHC molecules have been extensively examined for how they alter T cell activation, but many fewer studies have examined the TCR. Structural studies of how TCR differences alter T cell specificity have focused on broad variation in the CDR3 loops. However, changes in the CDR1 and 2 loops can also alter TCR recognition of pMHC. In this study we focus on two mutations in the CDR1 loop of the TCR that increased the affinity of a TCR for agonist Hb(64-76)/I-Ek by… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

T-cell tolerance: central and peripheral.

  • Cold Spring Harbor perspectives in biology
  • 2012
VIEW 1 EXCERPT

Signaling in thymic selection.

  • Current opinion in immunology
  • 2011
VIEW 1 EXCERPT

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