uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study.

@article{Lootens2009uPASCIDMW,
  title={uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study.},
  author={Leen Lootens and Philip Meuleman and {\'O}scar J Pozo and Peter Van Eenoo and Geert Leroux-Roels and Frans T Delbeke},
  journal={Clinical chemistry},
  year={2009},
  volume={55 10},
  pages={1783-93}
}
BACKGROUND Adequate detection of designer steroids in the urine of athletes is still a challenge in doping control analysis and requires knowledge of steroid metabolism. In this study we investigated whether uPA(+/+)-SCID mice carrying functional primary human hepatocytes in their liver would provide a suitable alternative small animal model for the investigation of human steroid metabolism in vivo. METHODS A quantitative method based on liquid chromatography-tandem mass spectrometry (LC-MS… CONTINUE READING
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