• Corpus ID: 37587894

ttention-Deficit / Hyperactivity Disorder ndophenotypes

  title={ttention-Deficit / Hyperactivity Disorder ndophenotypes},
  author={L Doyle and Erik G. Willcutt and Larry J. Seidman and Joseph Biederman and Virginie-Anne Chouinard and ulie Silva and Stephen V. Faraone},
ttention-deficit/hyperactivity disorder (ADHD) is a highly heritable disorder with a multifactorial pattern of inheritance. For complex onditions such as this, biologically based phenotypes that lie in the pathway from genes to behavior may provide a more powerful arget for molecular genetic studies than the disorder as a whole. Although their use in ADHD is relatively new, such “endophenotypes” ave aided the clarification of the etiology and pathophysiology of several other conditions in… 

Tables from this paper

Interference control in attention-deficit/hyperactivity disorder: differential Stroop effects for colour-naming versus counting

Two computerized versions of the Stroop (Colour-Stroop, Counting Stroop) which allowed to calculate separate measures of speed and accuracy, provided a more rigorous approach to calculate interference, and permitted to investigate the effects of stimulus properties on interference.



Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?

Evidence supporting the use of deficits on neurocognitive measures of executive functions for ADHD is reviewed and empirical strategies that may be necessary to allow such research to progress prior to full resolution of the pathophysiological basis of ADHD are discussed.

Heterogeneity in Attention-Deficit / yperactivity Disorder : Do We Need europsychologically Impaired Subtypes ? oel

efore assigning full etiologic validity to a psycopathologic disorder, disease theory suggests that a causal dysfunction in a mechanism ithin the affect individuals must be identified. Existing

Molecular Genetics of Attention-Deficit/Hyperactivity Disorder

Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes

It is proposed that three such endophenotypes — a specific abnormality in reward-related circuitry that leads to shortened delay gradients, deficits in temporal processing that result in high intrasubject intertrial variability, and deficits in working memory — are most amenable to integrative collaborative approaches that aim to uncover the causes of ADHD.

Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity.

The results replicate and extend previous findings of the association between the DAT1 gene and childhood ADHD and represent one of the first replicated relations of a candidate gene and a psychiatric disorder in children.

Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins.

A significant association of the exon 3 3-repeat allele with a novel talkative/impulsive latent-class-defined subtype of ADHD is found.

Deficient response inhibition as a cognitive endophenotype of ADHD.

Siblings of ADHD probands, while not behaviorally expressing the disorder, have ADHD-associated deficits in response inhibition, which suggests that subtyping based on measures of response inhibition can help identify genetic susceptibility to ADHD.

Genetics of attention deficit/hyperactivity disorder: are we ready for molecular genetic studies?

  • R. Todd
  • Psychology, Biology
    American journal of medical genetics
  • 2000
It is concluded that advances in identifying mutations or allelic variations in genes predisposing to ADHD are likely, but the general replication of such findings must await a better characterization of the heritable phenotypic elements of ADHD and a better understanding of its genetic heterogeneity.

Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder

Evidence is reviewed suggesting that parsing ADHD subjects based on comorbidity with conduct and bipolar disorders may yield familial subtypes that are suitable for genetic analyses.