trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

 trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3},
  author={Fabienne Lamballe and R{\"u}diger Klein and Mariano Barbacid},
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
  • M. Barbacid
  • Biology
    Annals of the New York Academy of Sciences
  • 1995
Characterization of mutant mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system.
The Trk family of neurotrophin receptors.
Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception.
Expression of the proto-oncogene, trk, receptors in the developing rat retina.
The developmental regulation of the high-affinity neurotrophin receptors in the rat retina is evaluated using polyclonal antibodies directed to a highly conserved region of the C-terminus of the p140trkA isoforms (pantrk) and antibodies directedto unique amino-acid sequences of p140 TrkA, p145trkB, and p 140trkC.
The TrK Receptor Family
The Trk receptors primarily bind and signal through Shc, FRS2, and PLCγ, which in turn activate PI3K, the Erks, and the hydrolysis of inositol phospholipids, leading to the modulation of gene transcription.
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
Insight is provided into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects.
A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
The expression and purification of the second Ig-like domain of human TrkB (TrkBIg(2) is described and it is shown that this domain is sufficient to bind BDNF and NT-4 with subnanomolar affinity.


trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
In situ hybridization analysis of 14 and 18 day old mouse embryos indicates thattrkB transcripts are localized in the central (CNS) and peripheral (PNS) nervous systems, including brain, spinal cord, spinal and cranial ganglia, paravertebral trunk of the sympathetic nervous system and various innervation pathways, suggesting that trkB may code for a novel cell surface receptor involved in neurogenesis.
Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.
The expression of trkB, a TK receptor, in early embryogenesis, and specifically in neural tissues, is consistent with the notion that this gene plays a role in the events that regulate the development of the nervous system.
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF.
Molecular and biochemical characterization of the human trk proto-oncogene
Results indicate that the product of the human trk locus is a novel tyrosine kinase cell surface receptor for an as yet unknown ligand.