trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

@article{Squinto1991trkB,
  title={
 trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor},
  author={S. Squinto and T. Stitt and T. Aldrich and S. Davis and Stella M. Blanco and C. Radziejewski and D. Glass and P. Masiakowski and M. Furth and D. Valenzuela and P. Distefano and G. Yancopoulos},
  journal={Cell},
  year={1991},
  volume={65},
  pages={885-893}
}
A variety of findings seem to functionally link brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), while distinguishing both of these factors from the third member of the neurotrophin family, nerve growth factor (NGF). Here we demonstrate that all three of these neuronal survival molecules bind similarly to the low affinity NGF receptor, but that BDNF and NT-3, unlike NGF, do not act via the high affinity NGF receptor. However, both BDNF and NT-3, but not NGF, bind to full… Expand
Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor
TLDR
It is demonstrated that TrkB mediates survival and proliferation in response to both BDNF and NT-3 when expressed in a particular strain of NIH 3T3 fibroblasts, with BDNF the more potent ligand. Expand
Binding of Neurotrophin-3 to p75, TrkA, and TrkB Mediated by a Single Functional Epitope Distinct from That Recognized by TrkC (*)
TLDR
The mutant NT-3 described here may be of greater advantage than nativeNT-3 when a trophic activity needs to be specifically targeted to TrkC-expressing neurons and provides a monospecific neurotrophin for future therapeutic development. Expand
The Trk family of neurotrophin receptors.
  • M. Barbacid
  • Biology, Medicine
  • Journal of neurobiology
  • 1994
TLDR
Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception. Expand
TrkB: BDNF receptor (vertebrates) (Neurotrophin-4 receptor, NTRK2)
TLDR
Molecular analysis of the multiple transcripts encoded by the mouse and rat TRKB locus suggests the existence of additional TrkB receptor isoforms, which have a very short cytoplasmic tail containing a single Tyr residue responsible for interaction with phospholipase Cγ. Expand
The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growthExpand
Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins
TLDR
Comparative crosslinking indicates that NGF can recognize all trk receptor members, illustrating the large number of potential ligand-receptor interactions between neurotrophins and their receptors. Expand
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
  • M. Barbacid
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1995
TLDR
Characterization of mutant mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system. Expand
Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling
TLDR
The data suggest that naturally occurring truncated trkB receptors function as inhibitory modulators of neurotrophin responsiveness and the homodimerization of gp145trkB appears to be an essential step in activation of the BDNF signaling cascade. Expand
Receptors and signaling pathways of ciliary neurotrophic factor and the neurotrophins
TLDR
Although the neurotrophin and CNTF receptor systems differ drastically, they display certain parallels and both depend on ligand-induced dimerization of signal transducing receptor components to activate signaling. Expand
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB.
TLDR
A more precise mapping of the region(s) responsible for binding BDNF, NT-3, and NT-4 identified the second leucine-rich motif of TrkB as a functional unit capable of binding all three neurotrophins. Expand
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The trk proto-oncogene encodes a receptor for nerve growth factor
TLDR
The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor. Expand
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