• Corpus ID: 55974071

transcription-quantitative polymerase chain reaction analysis. Furthermore, the effects of TRIM52-AS1 on proliferation, cell migration and apoptosis were analyzed using a wound scratch assay, a 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assay and flow cytometric analysis, respectiv

@inproceedings{Liu2016transcriptionquantitativePC,
  title={transcription-quantitative polymerase chain reaction analysis. Furthermore, the effects of TRIM52-AS1 on proliferation, cell migration and apoptosis were analyzed using a wound scratch assay, a 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assay and flow cytometric analysis, respectiv},
  author={Zan Liu and Haiyan Yan and Shunyao Xia and Chunshan Zhang and Youcheng Xiu},
  year={2016}
}
Long non-coding RNAs (lncRNAs) are important regulators of gene expression, interacting with the major pathways of cell growth, proliferation, differentiation and survival. Alterations in the function of lncRNAs promote tumor formation, progression and metastasis. The purpose of the present study was to identify novel tumor suppressor lncRNAs, and elucidate their physiological function and mechanism in renal cell carcinoma (RCC). The results of the present study revealed that the expression of… 
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References

SHOWING 1-10 OF 36 REFERENCES
Long Non-coding RNA URHC Regulates Cell Proliferation and Apoptosis via ZAK through the ERK/MAPK Signaling Pathway in Hepatocellular Carcinoma
TLDR
It is concluded that high URHC expression can promote cell proliferation and inhibit apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway.
Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma
TLDR
The data suggested that lncRNA MALAT1 was a novel molecule involved in ccRCC progression, which provided a potential prognostic biomarker and therapeutic target and indicated that knockdown expression of MALat1 decreased renal cancer cell proliferation, migration, and invasion.
High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma.
TLDR
In vitro assays indicated that knockdown of SPRY4-IT1 reduced renal cancer cell proliferation, migration, and invasion, and suggested that lncRNA SPRy4- IT1 might be considered as a potential prognostic indicator and a potential target for therapeutic intervention in RC.
Long Noncoding RNA ANRIL Promotes Non–Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression
TLDR
This study reported that ANRIL expression was increased in NSCLC tissues, and its expression level was significantly correlated with tumor–node–metastasis stages and tumor size, providing novel insights on the function of lncRNA-driven tumorigenesis.
HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1
TLDR
HOTAIR expression may serve as a potentially important disease biomarker for the identification of high-risk gastric cancer patients and provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation and the ensuing malignant phenotype in both cultured and xenograft Gastric cancer cells.
UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution
TLDR
Investigation of the clinical significance and biological function of urothelial carcinoma-associated 1 in colorectal cancer demonstrated that UCA1 levels were markedly increased in CRC tissues and cells compared to controls, and this high level of U CA1 expression was significantly correlated with larger tumour size, less differentiated histology and greater tumour depth.
Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152.
Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p
TLDR
It is demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues and knockeddown impaired the proliferation and invasiveness of GBC cells, at least in part through affecting miRNA-218-5p-mediated regulation of Bmi1.
The lncRNA-MYC regulatory network in cancer
TLDR
Progress is summarized on the interplay between lncRNAs and MYC in cancer to reveal the significance of lncRNA-MYC network in regulating initiation, development, and metastasis of tumors, and further research and collection of clinical data would provide a better understanding of l NCRNAs-MYCs network in cancer diagnosis and treatment.
Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma.
TLDR
In vitro assays indicated that downregulation of UCA1 decrease cell proliferation, migration, and invasion ability, which provides a potential prognostic biomarker and therapeutic target.
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