trans activation of gene expression by v-myb.

  title={trans activation of gene expression by v-myb.},
  author={C E Iba{\~n}ez and Joseph S Lipsick},
  journal={Molecular and cellular biology},
  volume={10 5},
The v-myb oncogene causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its product, p48v-myb, is a short-lived nuclear protein which binds DNA. We demonstrate that p48v-myb can function as a trans activator of gene expression in transient DNA transfection assays. trans activation requires the highly conserved amino-terminal DNA-binding domain and the less highly conserved carboxyl-terminal domain of p48v-myb, both of which are required for… CONTINUE READING


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