trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining.

@article{Meek2007transAA,
  title={trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining.},
  author={Katheryn Meek and Pauline Douglas and Xiaoping Cui and Qi Ding and Susan P Lees-Miller},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 10},
  pages={3881-90}
}
Recent studies have established that DNA-dependent protein kinase (DNA-PK) undergoes a series of autophosphorylation events that facilitate successful completion of nonhomologous DNA end joining. Autophosphorylation at sites in two distinct clusters regulates DNA end access to DNA end-processing factors and to other DNA repair pathways. Autophosphorylation within the kinase's activation loop regulates kinase activity. Additional autophosphorylation events (as yet undefined) occur that mediate… CONTINUE READING

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