trans-Activation of PPAR a and Induction of PPAR a Target Genes by Perfluorooctane-Based Chemicals

@inproceedings{Shipley2004transActivationOP,
  title={trans-Activation of PPAR a and Induction of PPAR a Target Genes by Perfluorooctane-Based Chemicals},
  author={Jonathan M. Shipley and Christopher H. Hurst and Sue S. Tanaka and Fred L. DeRoos and John L. Butenhoff and Andrew M. Seacat and David J Waxman},
  year={2004}
}
Peroxisome proliferator-activated receptors (PPARs) are liganddependent transcription factors that activate target genes involved in lipid metabolism, energy homeostasis, and cell differentiation in response todiverse compounds, includingenvironmental chemicals. The liver-expressed receptor PPARa mediates peroxisome proliferative responses associated with rodent hepatocarcinogenesis. Previous studies have established that certain perfluorooctanesulfonamide-based chemicals (PFOSAs) alter lipid… CONTINUE READING

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