trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

  title={trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.},
  author={Dawn M Z Schmidt and Dewey Granville McCafferty},
  volume={46 14},
The catalytic domain of the flavin-dependent human histone demethylase lysine-specific demethylase 1 (LSD1) belongs to the family of amine oxidases including polyamine oxidase and monoamine oxidase (MAO). We previously assessed monoamine oxidase inhibitors (MAOIs) for their ability to inhibit the reaction catalyzed by LSD1 [Lee, M. G., et al. (2006) Chem. Biol. 13, 563-567], demonstrating that trans-2-phenylcyclopropylamine (2-PCPA, tranylcypromine, Parnate) was the most potent with respect to… CONTINUE READING


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