trans-1,4,5,6-Tetrahydro-2-(3-hydroxystyryl)-1-methyl pyrimidine (CP-14,445), A New Antiwhipworm Agent

  title={trans-1,4,5,6-Tetrahydro-2-(3-hydroxystyryl)-1-methyl pyrimidine (CP-14,445), A New Antiwhipworm Agent},
  author={H. L. Howes},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={394 - 398}
  • H. L. Howes
  • Published 1972
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
  • Summary The antiwhipworm activity of CP-14,445, the meta-oxyphenyl analog of pyrantel, was described. In dogs it was more potent as the HCl salt than as the pamoate, but both forms were more potent than dichlorovos (Task). Dosage response data obtained from mouse and dog studies indicate that the T. muris-mouse infection, as a test model for antiwhipworm studies, has predictive value. 
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