trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.

The embryonic tracheal system in Drosophila develops from placodes of precursor cells on the ectoderm. A transcription factor of the basic helix-loop-helix (bHLH)-PAS family, which is expressed in the nuclei of the tracheal cells throughout development, was identified. The protein shows the highest degree of homology to the Single-minded (Sim) protein. The… CONTINUE READING