theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability.

@article{Banan2005thetaIO,
  title={theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability.},
  author={Ali Banan and Li Jia Zhang and Maliha W Shaikh and Jeremy Z. Fields and Sanjeev Choudhary and Christopher B Forsyth and Ashkan Farhadi and Ali Keshavarzian},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={313 3},
  pages={962-82}
}
Using monolayers of intestinal Caco-2 cells, we discovered that the isoform of protein kinase C (PKC), a member of the "novel" subfamily of PKC isoforms, is required for monolayer barrier function. However, the mechanisms underlying this novel effect remain largely unknown. Here, we sought to determine whether the mechanism by which PKC- disrupts monolayer permeability and dynamics in intestinal epithelium involves PKC--induced alterations in claudin isotypes. We used cell clones that we… CONTINUE READING

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