tert-BUTYLHYDROQUINONE IS A NOVEL ARYL HYDROCARBON RECEPTOR LIGAND

@article{Gharavi2005tertBUTYLHYDROQUINONEIA,
  title={tert-BUTYLHYDROQUINONE IS A NOVEL ARYL HYDROCARBON RECEPTOR LIGAND},
  author={Negar Gharavi and Ayman O. S. El-Kadi},
  journal={Drug Metabolism and Disposition},
  year={2005},
  volume={33},
  pages={365 - 372}
}
In contrast to the beneficial effects of tert-butylhydroquinone (tBHQ) as a food antioxidant, a number of studies have shown that chronic exposure to tBHQ may induce carcinogenicity. Therefore, we examined the ability of tBHQ to induce the cytochrome P450 1a1 (Cyp1a1), an enzyme known to play an important role in the chemical activation of xenobiotics to carcinogenic derivatives. A significant concentration-dependent increase in Cyp1a1 mRNA, protein, and activity occurred after treatment of… 

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Findings indicate that CYP1A1 may be induced by the antioxidant tBHQ via an AhR-dependent mechanism.

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