tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane.

@article{Csords2002tcBidPC,
  title={tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane.},
  author={Gy{\"o}rgy Csord{\'a}s and Muniswamy Madesh and Bruno Antonsson and Gy{\"o}rgy Hajn{\'o}czky},
  journal={The EMBO journal},
  year={2002},
  volume={21 9},
  pages={2198-206}
}
Calcium spikes established by IP(3) receptor-mediated Ca(2+) release from the endoplasmic reticulum (ER) are transmitted effectively to the mitochondria, utilizing local Ca(2+) interactions between closely associated subdomains of the ER and mitochondria. Since the outer mitochondrial membrane (OMM) has been thought to be freely permeable to Ca(2+), investigations have focused on IP(3)-driven Ca(2+) transport through the inner mitochondrial membrane (IMM). Here we demonstrate that selective… CONTINUE READING

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