tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.

@article{Lowe1997tRNAscanSEAP,
  title={tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.},
  author={Todd M. Lowe and Sean R. Eddy},
  journal={Nucleic acids research},
  year={1997},
  volume={25 5},
  pages={
          955-64
        }
}
We describe a program, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases. Two previously described tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which are then analyzed by a highly selective tRNA covariance model. This work represents a practical application of RNA covariance models, which are general, probabilistic secondary structure profiles based on stochastic… Expand
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