tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans

@inproceedings{Aeby2010tRNASecIT,
  title={tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans},
  author={Eric Aeby and Elisabetta Ullu and Hasmik Yepiskoposyan and Bernd Schimanski and Isabel Roditi and Oliver M{\"u}hlemann and Andr{\'e} Schneider},
  booktitle={Nucleic acids research},
  year={2010}
}
Nuclear-encoded tRNAs are universally transcribed by RNA polymerase III (Pol-III) and contain intragenic promoters. Transcription of vertebrate tRNA(Sec) however requires extragenic promoters similar to Pol-III transcribed U6 snRNA. Here, we present a comparative analysis of tRNA(Sec) transcription in humans and the parasitic protozoa Trypanosoma brucei, two evolutionary highly diverged eukaryotes. RNAi-mediated ablation of Pol-II and Pol-III as well as oligo-dT induced transcription… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Evolution of the Protein Synthesis Machinery and Its Regulation

Greco Hern, ndez, Rosemary Jagus
Springer International Publishing • 2016

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Close association of RNA polymerase II and many transcription factors with Pol III genes.

Proceedings of the National Academy of Sciences of the United States of America • 2010

The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Similar Papers

Loading similar papers…