tRNAPro -mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection.

@article{Nam2016tRNAProD,
  title={tRNAPro -mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection.},
  author={Daesil Nam and Eunna Choi and Dongwoo Shin and Eun-Jin Lee},
  journal={Molecular microbiology},
  year={2016},
  volume={102 2},
  pages={
          221-232
        }
}
Bacterial ribosome requires elongation factor P to translate fragments harbouring consecutive proline codons. Given the abundance of ORFs with potential EF-P regulated sites, EF-P was assumed to be constitutively expressed. Here, we report that the intracellular pathogen Salmonella enterica serovar Typhimurium decreases efp mRNA levels during course of infection. We determined that the decrease in efp mRNA is triggered by low levels of charged tRNAPro , a condition that Salmonella experiences… CONTINUE READING
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