tRNAHis-guanylyltransferase establishes tRNAHis identity

  title={tRNAHis-guanylyltransferase establishes tRNAHis identity},
  author={Ilka Ursula Heinemann and Akiyoshi Nakamura and Patrick O'Donoghue and Daniel Eiler and Dieter S{\"o}ll},
  booktitle={Nucleic acids research},
Histidine transfer RNA (tRNA) is unique among tRNA species as it carries an additional nucleotide at its 5' terminus. This unusual G(-1) residue is the major tRNA(His) identity element, and essential for recognition by the cognate histidyl-tRNA synthetase to allow efficient His-tRNA(His) formation. In many organisms G(-1) is added post-transcriptionally as part of the tRNA maturation process. tRNA(His) guanylyltransferase (Thg1) specifically adds the guanylyate residue by recognizing the tRNA… CONTINUE READING


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