tRNA punctuation model of RNA processing in human mitochondria

  title={tRNA punctuation model of RNA processing in human mitochondria},
  author={Deanna K. Ojala and Julio Montoya and Giuseppe M. Attardi},
A 3′-end proximal segment of most of the putative mRNAs encoded in the heavy strand of HeLa cell mtDNA has been partially sequenced and aligned with the DNA sequence. In all cases, the 3′-end nucleotide of the individual mRNA coding sequences has been found to be immediately contiguous to a tRNA gene or another mRNA coding sequence. These and previous results indicate that the heavy (H) strand sequences coding for the rRNA, poly (A)-containing RNA and tRNA species form a continuum extending… CONTINUE READING
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