tRNA punctuation model of RNA processing in human mitochondria

@article{Ojala1981tRNAPM,
  title={tRNA punctuation model of RNA processing in human mitochondria},
  author={Deanna Ojala and Julio Montoya and Giuseppe Attardi},
  journal={Nature},
  year={1981},
  volume={290},
  pages={470-474}
}
A 3′-end proximal segment of most of the putative mRNAs encoded in the heavy strand of HeLa cell mtDNA has been partially sequenced and aligned with the DNA sequence. In all cases, the 3′-end nucleotide of the individual mRNA coding sequences has been found to be immediately contiguous to a tRNA gene or another mRNA coding sequence. These and previous results indicate that the heavy (H) strand sequences coding for the rRNA, poly (A)-containing RNA and tRNA species form a continuum extending… 

Mitochondrial poly(A) polymerase is involved in tRNA repair

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Transfer RNA editing in land snail mitochondria.

  • S. YokoboriS. Pääbo
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
It is suggested that this form of RNA editing may involve polyadenylylation of the maturing tRNAs as an intermediate in order to restore base-pairing in the stems of land snails.
...

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