tRNA-like structures and gene regulation at the translational level: a case of molecular mimicry in Escherichia coli.

@article{Springer1989tRNAlikeSA,
  title={tRNA-like structures and gene regulation at the translational level: a case of molecular mimicry in Escherichia coli.},
  author={Mathias Springer and Monique Graffe and J Dondon and Marianne Grunberg-Manago},
  journal={The EMBO journal},
  year={1989},
  volume={8 8},
  pages={2417-24}
}
Escherichia coli threonyl-tRNA synthetase regulates the translation of its own mRNA by binding to it in a region, called the operator, located in front of the ribosomal binding site. The primary and secondary structures of the operator resemble those of the anticodon arm of several tRNA(Thr) isoacceptor species. We reasoned that if the interaction between the synthetase and its two partially analogous ligands, the tRNA and the mRNA, had some common features, single mutations in the enzyme… CONTINUE READING