tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response


The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers an intracellular signaling pathway, the unfolded protein response (UPR), that leads to increased transcription of genes encoding ER-resident proteins. Transcriptional activation is mediated by a dedicated transcription factor, Hac1p, whose activity is controlled by regulated… (More)
DOI: 10.1016/S0092-8674(00)81361-6


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