tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression

  title={tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression},
  author={Simon P Keam and Gyorgy Hutvagner and Llu{\'i}s Ribas de Pouplana and Adrian G Torres},
This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs-known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also… CONTINUE READING
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