tRNA Binding to Antitumor Drug Doxorubicin and Its Analogue

Abstract

The binding sites of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with tRNA were located, using FTIR, CD, fluorescence spectroscopic methods and molecular modeling. Different binding sites are involved in drug-tRNA adducts with DOX located in the vicinity of A-29, A-31, A-38, C-25, C-27, C-28, G-30 and U-41, while… (More)
DOI: 10.1371/journal.pone.0069248

Topics

8 Figures and Tables

Slides referencing similar topics