tRNA–mRNA mimicry drives translation initiation from a viral IRES

  title={tRNA–mRNA mimicry drives translation initiation from a viral IRES},
  author={David A. Costantino and Jennifer S. Pfingsten and Robert P. Rambo and Jeffrey S Kieft},
  journal={Nature Structural &Molecular Biology},
Internal ribosome entry site (IRES) RNAs initiate protein synthesis in eukaryotic cells by a noncanonical cap-independent mechanism. IRESes are critical for many pathogenic viruses, but efforts to understand their function are complicated by the diversity of IRES sequences as well as by limited high-resolution structural information. The intergenic region (IGR) IRESes of the Dicistroviridae viruses are powerful model systems to begin to understand IRES function. Here we present the crystal… CONTINUE READING
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