tRNA's modifications bring order to gene expression.

  title={tRNA's modifications bring order to gene expression.},
  author={Estella M. Gustilo and Franck A. P. Vendeix and Paul F. Agris},
  journal={Current opinion in microbiology},
  volume={11 2},
The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticodon domain control gene expression. Modifications at the anticodon's wobble position are required for recognition of rarely used codons and restrict or expand codon recognition depending on their chemistries. A shift of the translational reading frame occurs in the absence of… CONTINUE READING


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