t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy.

Abstract

Tert-butyloxycarbonyl (t-Boc)-based native chemical ligation (NCL) techniques commonly employ hydrogen fluoride (HF) to create the thioester fragment required for the ligation process. Our research aimed to assess the replacement of HF with Trifluoromethanesulfonic acid (TFMSA). Here we examined a 33 amino acid test peptide, Huwentoxin-I (HwTx-I) as a novel… (More)
DOI: 10.1002/bip.22887

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@article{Thapa2016tbocSO, title={t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy.}, author={Parashar Thapa and Chino C. Cabalteja and Edwin E Philips and Michael J. Espiritu and Steve Peigneur and Bea Garcia Mille and Jan Tytgat and Theodore R. Cummins and J K Bingham}, journal={Biopolymers}, year={2016}, volume={106 5}, pages={737-45} }