t-SNARE Protein Conformations Patterned by the Lipid Microenvironment*

@inproceedings{Rickman2010tSNAREPC,
  title={t-SNARE Protein Conformations Patterned by the Lipid Microenvironment*},
  author={Colin Rickman and Claire N. Medine and Alison R. Dun and David J. Moulton and Ondřej Mandula and Nagaraj D. Halemani and Silvio O Rizzoli and Luke H Chamberlain and Rory R. Duncan},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
The spatial distribution of the target (t-)SNARE proteins (syntaxin and SNAP-25) on the plasma membrane has been extensively characterized. However, the protein conformations and interactions of the two t-SNAREs in situ remain poorly defined. By using super-resolution optical techniques and fluorescence lifetime imaging microscopy, we observed that within the t-SNARE clusters syntaxin and SNAP-25 molecules interact, forming two distinct conformations of the t-SNARE binary intermediate. These… CONTINUE READING
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