t-Butyldimethylsilyl derivatives in the gas chromatography-mass spectrometry of steroids.

@article{Gaskell1976tButyldimethylsilylDI,
  title={t-Butyldimethylsilyl derivatives in the gas chromatography-mass spectrometry of steroids.},
  author={Simon J. Gaskell and C. J. W. Brooks},
  journal={Biochemical Society transactions},
  year={1976},
  volume={4 1},
  pages={111-3}
}
Hydroxylic compounds are usually converted into derivatives for analysis by g.1.c. and gas chromatography-mass spectrometry (g.1.c.-m.s.). Trimethylsilyl ethers have found the widest application, but other alkylsilyl derivatives (cf. Harvey & Paton, 1975) and halogenated analogues are of complementary value. Particular interest attaches to t-butyldimethylsilyl ethers ; they are more stable towards hydrolysis and have been used as protecting groups in synthesis (e.g. Corey & Venkateswarlu, 1972… CONTINUE READING