t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement

@article{Kuo2011t1118q21q21TA,
  title={t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement},
  author={Sung-Hsin Kuo and Ann-Lii Cheng and Chung-Hui Lin and Chih-Hung Hsu and Ming-Shiang Wu and Kun-Huei Yeh and Y. S. Tzeng and L T Chen},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2011},
  volume={68},
  pages={1387-1395}
}
PurposeActivation of TNF-α/NF-κB-related signaling pathway is crucial in sustain the growth of Helicobacter pylori-independent gastric mucosa-associated lymphoid tissue type (MALT) lymphoma. Thalidomide is an anti-angiogenic agent with anti-TNF-α and anti-NF-κB activity. This retrospective study evaluated the efficacy of thalidomide in standard therapy-failure gastric MALT lymphoma.MethodsBetween October 2003 and September 2007, 10 patients with antibiotics-resistant, chemotherapy-refractory… CONTINUE READING

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