t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth.

  title={t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth.},
  author={Stephen M Ansell and Takashi Akasaka and E. Frederick McPhail and Michelle M Manske and Esteban Braggio and Tammy L. Price-Troska and Steven C. Ziesmer and Frank J. Secreto and Rafael Fonseca and Mamta Aryabhushan Gupta and Mark Law and Thomas E Witzig and Martin J S Dyer and A. Latif Dogan and James R. Cerhan and Anne J. Novak},
  volume={120 19},
Genetic aberrations, including trisomies 3 and 18, and well-defined IGH translocations, have been described in marginal zone lymphomas (MZLs); however, these known genetic events are present in only a subset of cases. Here, we report the cloning of an IGH translocation partner on chromosome X, t(X;14)(p11.4;q32) that deregulates expression of an poorly characterized orphan G-protein-coupled receptor, GPR34. Elevated GPR34 gene expression was detected independent of the translocation in multiple… CONTINUE READING


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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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